Recently, I was introduced through a TV show to a young man, George Dennehy, who has done just that- and it is a remarkable story.
This 20-year-old was born without any arms, and yet, he is an amazing musician, who uses his feet to fret and strum chords.
Please check him out. I am sure that you also will be amazed and inspired by him.
George playing "Iris" on the guitar
George playing "in concert" with the Goo Goo Dolls
George Dennehy's Official YouTube Channel